
CRT0066101 dihydrochloride
CAS No. 1883545-60-5
CRT0066101 dihydrochloride ( CRT-0066101 | CRT 0066101 )
Catalog No. M12931 CAS No. 1883545-60-5
A potent, specific, orally active pan-PKD (protein kinase D) inhibitor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 65 | Get Quote |
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10MG | 110 | Get Quote |
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25MG | 222 | Get Quote |
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50MG | 354 | Get Quote |
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100MG | Get Quote | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameCRT0066101 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, specific, orally active pan-PKD (protein kinase D) inhibitor.
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DescriptionA potent, specific, orally active pan-PKD (protein kinase D) inhibitor with biochemical IC50 of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively; shows selectivity against a panel of > 90 protein kinases including PKCα/PKBα/MEK/ERK/c-Raf/c-Src/c-Abl; reduces bromodeoxyuridine incorporation, increases apoptosis, blocks neurotensin-induced PKD1/2 activation and reduces neurotensin-induced, PKD-mediated Hsp27 phosphorylation, attenuated PKD1-mediated NF-kappaB activation in pancreatic cancer cells; potently blocks tumor growth in vivo.
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In Vitro——
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In Vivo——
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SynonymsCRT-0066101 | CRT 0066101
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PathwayApoptosis
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TargetPKD
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RecptorPKD
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Research Area——
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Indication——
Chemical Information
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CAS Number1883545-60-5
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Formula Weight411.33
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Molecular FormulaC18H22N6O.2HCl
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 25 mg/mL 66.69 mM
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SMILESOC1=CC=C(C2=CN(C)N=C2)C=C1C3=NC=CC(NC[C@H](N)CC)=N3.[H]Cl.[H]Cl
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Chemical Name2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Harikumar KB, et al. Mol Cancer Ther. 2010 May;9(5):1136-46.
2. Thrower EC, et al. Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G120-9.
3. Borges S, et al. Mol Cancer Ther. 2015 Jun;14(6):1306-16.
4. Coughlan KA, et al. J Biol Chem. 2016 Mar 11;291(11):5664-75.
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