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CRT0066101 dihydrochloride

CAS No. 1883545-60-5

CRT0066101 dihydrochloride ( CRT-0066101 | CRT 0066101 )

Catalog No. M12931 CAS No. 1883545-60-5

A potent, specific, orally active pan-PKD (protein kinase D) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 222 Get Quote
50MG 354 Get Quote
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Biological Information

  • Product Name
    CRT0066101 dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, specific, orally active pan-PKD (protein kinase D) inhibitor.
  • Description
    A potent, specific, orally active pan-PKD (protein kinase D) inhibitor with biochemical IC50 of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively; shows selectivity against a panel of > 90 protein kinases including PKCα/PKBα/MEK/ERK/c-Raf/c-Src/c-Abl; reduces bromodeoxyuridine incorporation, increases apoptosis, blocks neurotensin-induced PKD1/2 activation and reduces neurotensin-induced, PKD-mediated Hsp27 phosphorylation, attenuated PKD1-mediated NF-kappaB activation in pancreatic cancer cells; potently blocks tumor growth in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    CRT-0066101 | CRT 0066101
  • Pathway
    Apoptosis
  • Target
    PKD
  • Recptor
    PKD
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1883545-60-5
  • Formula Weight
    411.33
  • Molecular Formula
    C18H22N6O.2HCl
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 25 mg/mL 66.69 mM
  • SMILES
    OC1=CC=C(C2=CN(C)N=C2)C=C1C3=NC=CC(NC[C@H](N)CC)=N3.[H]Cl.[H]Cl
  • Chemical Name
    2-[4-[[(2R)-2-aminobutyl]amino]-2-pyrimidinyl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Harikumar KB, et al. Mol Cancer Ther. 2010 May;9(5):1136-46. 2. Thrower EC, et al. Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G120-9. 3. Borges S, et al. Mol Cancer Ther. 2015 Jun;14(6):1306-16. 4. Coughlan KA, et al. J Biol Chem. 2016 Mar 11;291(11):5664-75.
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